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Success Rates of Clomid: What It is & How It Works

This article has been medically reviewed by a Reproductive Endocrinologist specializing in the treatment of fertility and complex reproductive disorders with Fertility Cloud.

The Clomid Cycle

Clomid is a commonly prescribed fertility drug used in the treatment of infertility. It is the first fertility medication that many doctors suggest for patients struggling to conceive. Clomid has been shown to improve the chances of conception and is the most prescribed fertility drug in the world. This article provides an overview of the information necessary for individuals considering taking Clomid to improve their chances of getting pregnant.


What is Clomid and How does it work?

Clomid (Clomiphene Citrate) is an oral medication prescribed by a doctor for those assigned female at birth who either do not ovulate regularly or need to increase their odds of getting pregnant. The medication works by decreasing the brain's perception of estrogen levels, causing the body to increase its production of the follicle stimulating hormone (FSH) and the luteinizing hormone (LH). This stimulates the growth of follicles, with the goal of ovulation induction - the growth of one follicle - for those with ovulation disorders and ovarian stimulation - the development of multiple follicles - for those with other reproductive disorders such as male factor or unexplained infertility.

Who Should not Take Clomid? Clomid may not be suitable for individuals with blocked fallopian tubes, low ovarian reserve, or significant age-related fertility decline, as well as those with endometriosis. Furthermore, those with any of these conditions should consider other treatment options.

Success Rates of Clomid

Success rates with Clomid vary depending on several factors, such as age and the cause associated with subfertility. For example, the probability of success decreases with increasing age due to egg quality. However, if subfertility is due to ovulatory dysfunction, Clomid success rates are much higher, with up to 80 percent of patients ovulating. While there is a discrepancy between ovulation and pregnancy rates with Clomid, the average success rate over several cycles is around 30 percent, depending on the diagnosis. Studies have shown that those assigned female at birth with polycystic ovary syndrome (PCOS) had a 27.4 percent pregnancy rate when using Clomid and timed intercourse for up to 5 cycles as confirmed by this 2014 study. The success rate of Clomid may also depend on whether it is used alone or in combination with other fertility treatments such as Intrauterine Insemination IUI or in vitro fertilization IVF. One study showed a 10-percent chance of pregnancy with Clomid during an IUI cycle, among those under 35 with open fallopian tubes and no male infertility issues. Can Men Take Clomid? It is possible for people assigned male at birth to take Clomid, yet the efficacy of this treatment is questionable. Several studies have examined the impact of Clomid on male infertility due to low sperm production and motility issues. Results have been varied, with some studies exhibiting a moderate increase in sperm count and others not demonstrating any improvement or increased pregnancy rate. At present, Clomid is being utilized as an initial option for those assigned male at birth with a normal systemic evaluation and low sperm count. Side effects of Clomid Clomid is frequently prescribed due to its mild side effect profile. However, it is important to be aware of potential side effects prior to taking the medication, which may include: Upset stomach Hot flashes Bloating Breast tenderness Headaches Dizziness Vision changes Heavy period Does Clomid increase my chances of having twins? Clomid has been shown to increase the likelihood of ovulation, and hence, the chance of conceiving twins. Research indicates that 5-12% of individuals with ovaries who have become pregnant with the help of Clomid have given birth to twins, and less than 1% have had triplets or higher order multiples. It is interesting to note that the majority of twins born from Clomid treatment are not identical, as identical twins result from one egg, rather than two. Where can I get Clomid? Clomid is a prescription drug and requires consultation with a doctor before use. Most OB/GYNs are able to prescribe Clomid, however those with more complex medical histories may need to consult with a fertility specialist. If you are considering Clomid, please reach out to your doctor to discuss your medical history and determine if it is the right choice for you. We are here to support you on your path to building the family of your dreams. For more information or assistance, please visit our contact page.

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